Strikingly, several other disease-associated mutations in CAV1 identified in patients with pulmonary arterial hypertension and/or lipodystrophy syndromes [34,93,101,105,107,111–113,115] cluster near the residues P158 and F160 in the structure, whereas another set of mutations are located in the scaffolding domain (Figure 6). Here, CAV1 is linked to pulmonary arterial hypertension.