Therefore, the correlation between CX3CL1 and ICAM‐1 or VCAM‐1 is explored in the present study, showing that only CX3CL1‐induced ICAM‐1 expression is observed, indicating that ICAM‐1 plays a vital role in CX3CL1‐induced cancer metastasis. This evidence concerns the gene VCAM1 and cancer.