DNMT3A and obesity due to melanocortin 4 receptor deficiency: Showing an increased expression in obesity, and described as acting primarily as a repressor of gene expression, DNMT3A association with lipidic profile and pro-inflammatory signals (e.g. IL-6, LPS) has been unclear.28 Here we observed alterations in DNMT3A gene expression patterns, associated with therapeutic response with slight differences between patients who were or are in treatment compared to CG.