Showing an increased expression in obesity, and described as acting primarily as a repressor of gene expression, DNMT3A association with lipidic profile and pro-inflammatory signals (e.g. IL-6, LPS) has been unclear.28 Here we observed alterations in DNMT3A gene expression patterns, associated with therapeutic response with slight differences between patients who were or are in treatment compared to CG. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.