The observation that the presence of CK-19 is associated with a good response to TA is in line with the results of a recent prospective study [23] comparing laser ablation to radiofrequency ablation for debulking benign nonfunctioning thyroid nodules and showing that volume reduction ranged between 53.2% and 64.3% 6 months after the procedure. The gene discussed is KRT19; the disease is thyroid nodule.