Jorgenson et al. conducted the first genome-wide association study and recognized four significant inguinal hernia risk loci (EBF2, ADAMTS6, EFEMP1 and WT1).16 It has been demonstrated that these four genes contribute to elastin maintenance and collagen equilibrium and are involved in the development of inguinal hernia. The gene discussed is ELN; the disease is Inguinal hernia.