Significant relations were reported among BPH and prostate cancer as BPH could augment risk of prostate cancer.33 WT1 also regulates the levels of E-cadherin, contributing to the migratory potential of prostate cancer cells.34 In addition, MMP-9, which is downregulated by WT1,32 has been identified as a potential prostate tumor marker, while overexpression of MMP-9 was observed in prostate cancers.35 Our result resembles the finding of a previous epidemiological study that showed BPH was associated with later inguinal hernia formation.36 Here, CDH1 is linked to benign prostatic hyperplasia.