Moreover, knockout of AKT22 or Serum- and glucocorticoid-regulated kinase 1 (SGK1)23 can inhibit UUO-induced renal fibrosis by activating GSK-3β, while lithium24, angiotensin II25 and highly circulating follicle stimulating hormone (FSH)26 can promote renal fibrosis by inhibiting GSK-3β. The gene discussed is BRD2; the disease is renal fibrosis.