GSK3B and renal fibrosis: Moreover, knockout of AKT22 or Serum- and glucocorticoid-regulated kinase 1 (SGK1)23 can inhibit UUO-induced renal fibrosis by activating GSK-3β, while lithium24, angiotensin II25 and highly circulating follicle stimulating hormone (FSH)26 can promote renal fibrosis by inhibiting GSK-3β.