GNRH1 and asthma: The results from metabolic pathway enrichment analysis of differential metabolites showed that in the positive ion mode, the top 3 enriched metabolic pathways that were significantly altered between two groups included Asthma (the 27th most up-regulated metabolite, histamine was enriched in this pathway), Fc epsilon RI signaling pathway (the 27th and 46th most up-regulated metabolites, histamine and arachidonic acid were enriched), and GnRH signaling pathway (the 46th most up-regulated metabolite, arachidonic acid was enriched).