CHUK and demyelinating disease: It has been reported that PIM3, a proto-oncogene with serine/threonine kinase activity, could regulate cell migration and apoptosis via PI3K–AKT, p38, or Rho GTPase signaling,56–58 and was related to demyelinating disease.59 Inhibitor-κB kinase α, which is encoded by the CHUK gene, was recognized to regulate NF-κB activity60 61 and involved the differentiation of mouse embryonic neuroectoderm.