In the central nervous system, a group of studies have demonstrated that NDRG2 expression is predominantly present in GFAP-positive astrocytes in brain parenchyma under the physiological or pathological condition (Okuda et al., 2008; Takeichi et al., 2011; Flugge et al., 2014; Takarada-Iemata et al., 2014, 2018) and in dystrophic neurons in Alzheimer’s disease (Mitchelmore et al., 2004). Here, NDRG2 is linked to early-onset autosomal dominant Alzheimer disease.