These macrophages express genes related to lipid metabolism (glycoprotein nmb (Gpnmb) and Spp1), which are also expressed in macrophages in mouse livers with non-alcoholic steatohepatitis (NASH) and obese adipose tissue, and are termed lipid-associated macrophages (LAMs) (Remmerie et al., 2020). The gene discussed is SPP1; the disease is metabolic dysfunction-associated steatohepatitis.