In mouse models of NASH, Ly6Chigh monocyte-derived MoMFs differentiate into LAMs (Remmerie et al., 2020; Tran et al., 2020), which express the gene signatures associated with lipid metabolism including Gpnmb, Spp1, Trem2, and Cd9 (Seidman et al., 2020) and localize in fibrotic areas (Daemen et al., 2021). This evidence concerns the gene SPP1 and metabolic dysfunction-associated steatohepatitis.