We performed GSVA enrichment analysis on OA samples and ND samples in datasets GSE55235 based on pathway information in intercellular communication, and nine signaling pathways (VISFATIN, SPP1, TGFb, PTN, MIF, PROS, ANGPTL, FGF, GAS) were enriched (Figure 8A). The gene discussed is PROS1; the disease is Norrie disease.