ACTA1 and hydrops fetalis: In the development of HF, hepatic stellate cells (HSCs) enter an activated state, and produce excessive collagen-based extracellular matrix (ECM) such as α-smooth muscle actin (α-SMA), thereby leading to the collagen deposition and inducing tissue fiberization, which is the key to the alteration in the normal structure and function of the liver tissues [5–7].