The mechanisms by which sleep disorders affect cardiovascular disease include: first, sleep deprivation leads to changes in leptin and ghrelin levels, which promote the development of obesity, and elevated blood sugar levels; second, sleep disorders can lead to changes in growth hormone metabolism and increased cortisol secretion; finally, mild inflammation caused by sleep disorders can increase the hypothalamic-pituitary-adrenal axis stress response, resulting in increased blood pressure, blood flow blockage, and increased risk of cardiovascular disease (Klop et al., 2013). This evidence concerns the gene GHRL and obesity disorder.