PCYOX1L and early-onset autosomal dominant Alzheimer disease: In this subtype, we found lower levels of Prenylcysteine Oxidase 1 Like (PCYOX1L), a gene which has been previously associated with Alzheimer’s disease,61–64 and has been identified as an Alzheimer’s disease target gene by the Agora platform (https://agora.adknowledgeportal.org/) with strong evidence for RNA down-regulation across eight brain regions and proteomic down-regulation across four regions.