In return, these TAMs will promote cancer cell growth and expansion by producing several factors that are known to expand the malignant clone, such as the epidermal growth factor (EGF) [28,35], platelet-derived growth factor (PDGF) [36], transforming growth factor B1 (TGF-B1), hepatocyte growth factor, and basic fibroblast growth factor (b-FGF) [36]. The gene discussed is EGF; the disease is cancer.