Age: Median 65 years, Sex: 57% male; Comorbidities: HTN, Diabetes, CKD, Asthma, COPD, Chronic liver disease (advanced fibrosis and cirrhosis, alcohol-related liver disease, NAFLD or NASH, HBV, HCV, Autoimmune hepatitis, Peak ALT/Initial ALT: >ULN 45%/24%; >5×ULN 6.4%/1.3%, Peak AST/Initial AST: >ULN 74%/56%; >5× ULN 13%/3.8% The gene discussed is GPT; the disease is chronic obstructive pulmonary disease.