In conclusion, the MEPIRAPIM analogue SB2193 has acute anticonvulsant effects in the 6 Hz mouse model of psychomotor seizures but not the Scn1a+/− mouse model of Dravet syndrome, nor the GAERS model of absence epilepsy. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.