Together with GPD2, SYNM ranked at the top three (MCC score = 17,16, respectively) as well, which have also been reported to be associated with mitochondrial function (Winter et al., 2015; Kuznetsov et al., 2020; Paulin et al., 2020; Baek et al., 2021), indicating its potential participation of mitochondria metabolism in AF. Here, GPD2 is linked to atrial fibrillation.