Some of the genes most notably detected in both LUAD and SCC tumor subtypes include TP53, RB1, ARID1A, CDKN2A, PIK3CA, and NFL. Of these gene, TP53, CDKN2A, and PIK3CA were found significantly in SCC tumor subtypes (p < 0.01). The gene discussed is RB1; the disease is neoplasm.