TP53 and non-small cell lung carcinoma: In studies that analyzed TP53 as a mutually exclusive mutation, the results suggest that presence of TP53 mutations in LUAD tumors are associated with NSCLC incidence at an earlier age, as well as a general significant increase in the mutational frequency of TP53 in AAs compared to other genetic mutations (Bollig-Fischer et al., 2015; Arbour et al., 2018; Arauz et al., 2020).