A few of these gene variants were also associated with overall lung cancer risk, and predisposition of NSCLC including: rs33658 (HNF1B gene in chromosome 5q14.3) associated with increased lung risk, rs7186207 (DHODH gene in chromosome 16q22.2) significantly associated with lower lung cancer risk, and rs11658063 (HAPLN1 gene in chromosome 17q12) associated with lower NSCLC risk (Jones et al., 2019). The gene discussed is DHODH; the disease is lung cancer.