The fatty hepatocyte in NAFLD is inevitably accompanied by mitochondrial dysfunction and the occurrence of hepatocyte degeneration and necrosis, inducing the production of inflammatory chemicals such as c-reactive protein, tumor necrosis factors α, interleukin-6, interleukin-12 and monocyte chemoattractant protein-1 in hepatocytes, leading to an inflammatory response in the liver, and systemic low-grade inflammatory response. The gene discussed is CRP; the disease is metabolic dysfunction-associated steatotic liver disease.