As indicated in Table 1, autoantibodies in BC sera significantly associated with invasive BC targeted protein-coding exonic regions of the PKM2 (Figure 2B), MAPK3 (Figure 3B), COX7A2 (Figure 3A), and TSPOAP1 (Figure 4B) genes, but only intronic regions of SPATA5 (Figure 3C). The gene discussed is PKM; the disease is breast cancer.