The data that we report here on the possible link between ERCC4 and BC together with our previous findings of autoreactive Ku antigen and the central role of RPA in DNA replication, recombination, and repair suggest that autoimmunity to ERCC4, Ku, and RPA32 reflects molecular changes involved in the process of tumorigenesis, in particular on the importance of NER in breast carcinogenesis. The gene discussed is RPA1; the disease is breast cancer.