The phage sequence targeted by BC autoantibodies maps near the ERCC4 gene (Figure 6A), which is involved in Nucleotide Excision Repair (NER) pathway and has been associated with risk of BC in a 2-stage case-control study in Spanish and Finnish populations and that variation of the gene was associated with a protective effect (Milne et al., 2006). This evidence concerns the gene ERCC4 and breast cancer.