Specifically, we identified autoreactive GAPDH and PKM2 clones (multi-cell line cDNA library) (Table 1; Supplementary Table S1); these genes play a key role in aerobic glycolysis and apoptosis, while GAPDH expression is also associated with BC cell proliferation and tumor aggressiveness (Guo et al., 2013). Here, GAPDH is linked to breast cancer.