In vitro studies indicated that LINC02381 may function as a tumor suppressor by regulating the phosphatidylinositol 3-kinase (PI3K-AKT) signaling pathway (Jafarzadeh et al., 2020) and more recently this was confirmed in vivo where a knockdown of the gene was found to hinder proliferation, migration and invasion of BC cells, while overexpression promoted carcinogenesis (Huang et al., 2022). This evidence concerns the gene AKT1 and neoplasm.