PIK3CA and breast cancer: In vitro studies indicated that LINC02381 may function as a tumor suppressor by regulating the phosphatidylinositol 3-kinase (PI3K-AKT) signaling pathway (Jafarzadeh et al., 2020) and more recently this was confirmed in vivo where a knockdown of the gene was found to hinder proliferation, migration and invasion of BC cells, while overexpression promoted carcinogenesis (Huang et al., 2022).