JNK activation is a cellular response to environmental inflammatory stresses, hence the GSTP1 being targeted by autoantibodies in BC is compatible with the hypothesis that autoimmune tissue damage in BC leads to chronic inflammation and tumorigenic signals (Fernández Madrid et al., 2015; Maroun et al., 2017; Aras et al., 2019) (Adler et al., 1999). This evidence concerns the gene GSTP1 and breast cancer.