Interestingly, the p53-target genes were frequently listed in the core subset genes across several activated pathways, and it is noteworthy that the top two frequent genes across all significant gene sets are NOTCH1 (24 occurrences) and CAV1 (23 occurrences), which reinforces the previous analysis showing the important subset of p53-target genes in HPV-associated HNSCC. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.