TP53 and head and neck squamous cell carcinoma: Given that in the case of HPV+ HNSCC, the p53 is inactivated by E6-E6AP, thus, we can suggest that the overexpression of the identified p53 target genes could be explained by the involvement of other pathways outside of p53, including the activation of alternative signaling pathways, such as the PI3K/Akt pathway (65).