However, the high level of MDM2 demonstrates significantly increased overall survival (HR= 0.461, 95%CI (0.291-0.728), p = 0.002) in HNSCC HPV+ patients, while no significant association (p = 0.263) was reported between the MDM2 expression and the overall survival of the HNSCC HPV- patients (Supplementary Figure 2B). Here, MDM2 is linked to head and neck squamous cell carcinoma.