MDM2 and head and neck squamous cell carcinoma: As expected, the MDM2 showed a very significant over-expression in HPV+ than in HPV- HNSCC patients (p = 2.39E-05) and in normal samples (p = 2.81E-07), however, only a slight difference was observed between HPV- HNSCC patients and normal samples (p = 0.03) (Supplementary Figure 1B).