To investigate the crosstalk between lipid metabolism and YY1 in liver cancer cells, the authors found that several key transcription factors of lipid metabolism and their coactivators were significantly reduced in YY1-knockout HCC cells, such as PPARA/RXRA complex member CHREBP, SREBF2 and FXR and HNF family member HNF4A, FOXA1 and FOXA2 (117–119). The gene discussed is YY1; the disease is hepatocellular carcinoma.