Likewise, several studies have shown that YY1 is highly expressed in breast cancer (15), bladder cancer (16), colorectal cancer (17), cervix cancer (18), esophageal carcinoma (19), gastric cancer (20), glioma (21), hodgkin lymphoma (22), hepatocellular carcinoma (23), kidney cancer (24), lung cancer (25), melanoma (26), osteosarcoma (27), ovary cancer (28), and prostate cancer (29). This evidence concerns the gene YY1 and central nervous system cancer.