The Hippo pathway, a regulator in several signaling processes, such as organ size, tissue homeostasis, cell proliferation and differentiation, plays a peculiar role in BC (36–38), where it is reported an overstimulation of the AKT kinase activity, also via the HER2 protein, resulting in the majority of cases in a higher-grade carcinoma (38, 39). Here, ERBB2 is linked to breast cancer.