One subject in the LZM008 group had four cases of TEAEs of grade IV, which occurred on day 3; we observed a decrease in absolute neutrophils, agranulocytosis, and percentage of neutrophils, and an increase in heterozygous lymphocytes, and 300 μg of granulocyte colony-stimulating factor (G-CSF) was administered for treatment of TEAEs on day 7. This evidence concerns the gene CSF3 and Absence of circulating granulocytes.