LGALS3 and heart failure: However, if it is the cause there may be a correlation between the two and with one exception there are significant correlations between the two well-known heart failure markers, Nppa and Nppb (responsible for ANP and BNP) and the macrophage marker, Cd14, the cytokine transcript, Crlf1, and the transcript for the cytokine-like galectin-3, Lgals3 (Supplementary Figure S21).