This is likely to be important, because in mice, loss-of-function of Cav1.3 and Cav3.1 impairs AV conduction and in humans AV block has been attributed to loss-of-function of Cav1.3 and Cav3.1 (Mesirca et al., 2015). The gene discussed is CACNA1D; the disease is atrioventricular block.