HSPG2 and cancer: In the precancerous stage of liver fibrosis and cirrhosis, the accumulation of inflammasome and inflammatory factors will intensify the transformation of cirrhosis to PLC; while in the tumor stage, when cancer cells are formed, pyroptosis is inhibited, forming an intrinsic malignant microenvironment that blocks cancer cell death and accelerates the progression of PLC to the malignant level.