FUN14 structural domain protein 1 (FUNDC1) is a characteristic mitogenic receptor in most human HCC, and knockdown of FUNDC1 activates NLRP3 inflammasome to promote hepatocarcinogenesis during diethylnitrosamine (DEN)-induced hepatocarcinoma in mice (83). The gene discussed is NLRP3; the disease is hepatocellular carcinoma.