According to one study, JAK2/STAT3 activity was significantly increased in rats with severe acute pancreatitis, and JAK2 inhibition increased levels of cytokines (such as Foxp3, IL-10, and TGF-β) necessary for M2 macrophage polarization, leading to a reduction in the secretion of pro-inflammatory factors IL-6, IFN-γ, and TNF-α, which prevents pancreatic inflammation and damage (40). This evidence concerns the gene JAK2 and acute pancreatitis.