STAT3 and rectal cancer: The Ca(2+)/calmodulin-dependent kinase II (CaMKII) pathway is one of the important atypical pathways of Wnt5a signaling, which is required to mediate the Ca(2+)/CaKMII/STAT3 pathway in macrophage M2 polarization, which then promotes the expression of IL-10, TGF-β, CCL17, CCL18 and CCL22, thereby promoting proliferation, migration and invasion of rectal cancer cells.