STAT3 and neoplasm: Type Iγ phosphatidylinositol phosphate kinase is a phosphatidylinositol kinase that produces phosphatidylinositol bisphosphate in cells and increases STAT3 phosphorylation by stimulating activation of the PI3K/AKT signaling pathway, which in turn promotes the C-C motif chemokine ligand 2 transcription to improve tumor-associated macrophage recruitment (99).