Among them, STAT3α, the most common isoform of STAT3, is generated by transcription and translation of the full-length STAT3 gene, which contains two phosphorylation sites of tyrosine and serine in the TAD region and can regulate the cellular response of macrophages to IL-6 and IL-10, and is involved in important biological processes such as immune regulation, cell proliferation and differentiation, and tumor cell proliferation and migration (20). The gene discussed is STAT3; the disease is neoplasm.