It was found that activation of Hh signaling could mediate the interaction between cancer cells such as hepatocellular carcinoma cells and mammary carcinoma cells and macrophages and stimulate selective polarization of macrophages toward the M2 subtype, increasing the expression of pro-tumor factors such as TNF-α, iNOS and IL-6, and ultimately promoting tumor growth and metastasis (111, 112). This evidence concerns the gene TNF and neoplasm.