TP53, CCND1, CDK4, STAT3, VEGFA, CDKN2A, MDM2, SRC, CHEK2, ERBB2, RB1, FOS, CCNE1, PLK1, MMP2, SIRT1, E2F2, CCNG1, and TNFSF11. The involvement of mutated genes TP53 and VEGFA is closely associated with all types of cancer. The gene discussed is PLK1; the disease is cancer.