ARF6 and osteosarcoma: The signaling pathways involved in tumor progression of Osteosarcoma are the FOXM1 transcription pathway, ATM signaling pathway, FAK mediated signaling events, Arf6 signaling events, Class 1 PI3K signaling events, mTOR signaling pathway, and Integrin family cell surface interactions (Supplementary File 4; Figure 4).