We thus selected a large cohort of DLBCL cases occurring in youth with relatively early‐stage disease confined to the head and neck region, to compare the clinicopathologic features of LBCL, IRF4+ and IRF4− ones, and to observe the prognostic implication of IRF4 rearrangement in these patients. This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.