For instance, miR‐28‐5p reduces cell proliferation, while induces cell cycle arrest and apoptosis in nasopharyngeal cancer,27 LOXL1‐AS1 promotes the development of pancreatic cancer by sponging miR‐28‐5p/SEMA7A axis,28 high miR‐28‐5p expression predicts poor OS in patients with non‐metastatic colorectal cancer.29 This evidence concerns the gene LOXL1 and metastatic colorectal cancer.