Moreover, co‐administration of G‐Rh2 and miR‐28‐5p antagomir exhibited higher inhibitory effects on tumor growth, and inductive effects on STK4 and p‐β‐catenin level, indicating the synergistic role of G‐Rh2 and miR‐28‐5p antagomir in NSCLC tumor growth in vivo by upregulating STK4 and inactivating Wnt signaling. This evidence concerns the gene STK4 and neoplasm.