EGFR and neoplasm: The variables that had a significant negative impact on five-year OS in Cox regression were age {HR 1.03 [95% confidence interval (CI) 1.001‒1.06]}, p16 negativity (HR 0.27 [95% CI 0.11‒0.69], p = 0.006), high EGFR expression (HR 1.86 [95% CI 1.07‒3.24]), cT4 (HR 3 [95% CI 1.7‒5.29]), extra-nodal tumor extension (HR 1.85 [95% CI 1.04‒3.28]), alcohol consumption (HR 2.17 [95% CI 1.06‒4.44]), and cigarette smoking (HR 2.06 [95% CI 1.09‒3.92]; all p < 0.05; Table 3).