The C1orf141 gene, with uncharacterized protein function, has overlapping regions with IL23R. Variants in the IL23R-C1orf141 region have been associated with susceptibility to Vogt-Koyanagi-Harada disease, a multi-system autoimmune disorder that affects pigmented tissues, in Chinese and Japanese populations [31, 54]. This evidence concerns the gene IL23R and Vogt-Koyanagi-Harada disease.