In addition, genetically predicted higher levels of waist-to-hip ratio adjusted body mass index (WHRadjBMI), fasting insulin, serum 25(OH)D, and serum calcium, whereas lower levels of years of education, and urine pH could elevate nephrolithiasis risk after FDR correction (FDR P < 0.05). The gene discussed is INS; the disease is nephrolithiasis.