CCR4 and liver disorder: Our previous data demonstrated that CCRs including CXCR1 and CXCR2 induce inflammation and hepatocyte death in HBV-related acute-on-chronic liver failure patients and blockade of these receptors by SCH 527,123 antagonist significantly inhibited cell death and inflammation by limiting the production of pro-inflammatory cytokines and reactive oxygen species (ROS) which signifies the potential role of CCRs during liver diseases [16]. The chemokine receptor 4 (CCR4) is expressed on circulating and tissue-resident T cells.