Additionally, exosomal miR-30d-5p from polymorphonuclear neutrophils contributes to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis by activating NF-κB signaling [25], indicating that neutrophils are critically involved in sepsis-induced ALI. Here, NFKB1 is linked to acute respiratory distress syndrome.