STAT3 and Eczematoid dermatitis: AD-HIES STAT3-Dominant Negative (DN) is recognized as a multisystem disorder with both immunologic and non-immunologic features, distinguished by a clinical trial of eczema, recurrent staphylococcal skin and lung infections, and elevated serum IgE levels (above 2000 UI/ml) due to loss-of-function (LOF) mutations of the signal transducer and activator of transcription 3 (STAT3) gene [2].