We further established relative timing of SNVs in several lower-prevalence driver genes (in order of increasing mRT): FBXW7, NOTCH1, CASP8, FAT1, NSD1, HRAS, EP300, CREBBP, KMT2D, PIK3CA, NFE2L2, HLA-A, SPEN and KMT2C. mRT values of events in the first nine genes were less than 0.69, supporting early roles in tumorigenesis before carcinoma in situ. Here, NOTCH1 is linked to cancer.