While α-PD-1 combined with GITR reprogramming of CD4+ T cells has been reported to improve ICB response in glioblastoma24, this is the first time the dynamic response of intratumoral Teff and Treg subsets to RT and RT + ICB is described and timely harnessed in poorly immunogenic glioblastoma. The gene discussed is CD4; the disease is glioblastoma.