Across the cohort, we observed increased interactions between myeloma cells and activated T cells upon elotuzumab treatment for HLA-DRB5-high MM samples compared to HLA-DRB5-low samples (Fig. 6k), suggesting that MHC-II-mediated antigen presentation associates with increased sensitivity to elotuzumab. The gene discussed is HLA-DRB5; the disease is Miyoshi myopathy.