Importantly, whereas endogenous CD44+CD8+ TILs mostly distributed across C4 (canonical TEX) and C2 (effector memory) at the time of tumor regression following PD1d/IL-2v/IL-33 ACT, the C5 TSE effector state identified above was a unique property of OT1 TILs (Fig. 3c and Supplementary Table 2). This evidence concerns the gene CD44 and neoplasm.