Moreover, upon mTORC1 inactivation via Raptor knockdown, the growth of reintroduction of WT p62, but not its ubiquitin-dead mutant, is significantly reduced in both cell culture setting (Fig. S7B, C) and nude mice xenograft model, when compared with each respective control group (Fig. S7D–G), suggesting that mTORC1 activation is the downstream event for TRAF2-p62 axis regulating liver cancer growth. This evidence concerns the gene SQSTM1 and liver cancer.