Moreover, we found that ectopic expression of FLAG-TRAF2 in TRAF2 deleted HCC cells increased the levels of phosphorylated S6K1 and decreased p62 (Fig. S10, lanes 2 vs 1), and bafilomycin A1, an inhibitor of lysosome, abrogated p62 reduction and had no effect on phosphorylated S6K1 (Fig. S10, lanes 4 vs 2 and 1), suggesting ubiquitinated p62 by TRAF2 is degraded by lysosome. Here, SQSTM1 is linked to hepatocellular carcinoma.