EIF4EBP1 and neoplasm: We found that the growth of Huh7-sgTRAF2-shp62-shRaptor, but not Huh7-sgTRAF2-shRaptor cells, was significantly inhibited along with decreased levels of p-S6K1, p-S6, and p-4EBP1, the well-known markers of mTORC1 activity, in vitro cell-based and in vivo nude mice tumor formation-based settings, when compared with each respective control cells (Fig. S6C–H).