In the prognostic analysis of disease-free interval (DFI), CYP4B1 (p = 0.003) and FAM83A (p = 0.003) had the highest effect on the disease-free progression of lung adenocarcinoma, while KRT6A (p = 0.046) had a higher effect on BRCA. Here, CYP4B1 is linked to lung adenocarcinoma.