High expression of KRT6A (HR = 1.108, 95%CI = 1.004–1.223) and FAM83A (HR = 1.227, 95%CI = 1.074–1.402) had a poor prognostic progression of BRCA and lung adenocarcinoma, while CYP4B1 had the opposite effect on lung adenocarcinoma (HR = 0.860, 95%CI = 0.778–0.950). The gene discussed is CYP4B1; the disease is lung adenocarcinoma.