High expression of KRT6A (HR = 1.125, 95%CI = 1.047–1.207) and FAM83A (HR = 1.288, 95%CI = 1.138–1.457) was associated with poor DSS of lung adenocarcinoma, while CYP4B1 had the opposite effect on lung adenocarcinoma. The gene discussed is KRT6A; the disease is lung adenocarcinoma.