Genome-wide association studies (GWASs) have shown several single nucleotide polymorphisms (SNPs), e.g., rs738409-G in patatin‐like phospholipase domain containing 3 (PNPLA3)11, rs58542926-T in transmembrane 6 superfamily member 2 (TM6SF2)12, rs13107325-T in solute carrier family 39 member 8 (SLC39A8)13, rs6834314-A in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13)14 and rs1260326-T in glucokinase regulator (GCKR)15,16 associated with NAFLD-related comorbidities. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.