CRP and infection: Indeed, IL6 and presepsin are the first ones to increase in peripheral blood after the onset of the infection, with a time of increasing of 1 and 2 h respectively and a peak at 4 and 3 h respectively, while PCT starts increasing at 3–4 h and peaks at 8–24 h and CRP starts rising at 4–6 h with a peak at 36–48 hours35.