In conclusion, several immune and TLR signaling pathway related feature lncRNAs may be the candidate biomarkers of AIS diagnosis, including LINC00173, LINC01089, LINC02210, MIR600HG, SNHG14, TP73-AS1, LINC00680 and CASC2, providing the potential for TLR signaling pathway as the promising avenue for AIS immune therapeutic target. This evidence concerns the gene LINC00680 and androgen insensitivity syndrome.