IL-6 levels of the non-infected groups were all slightly similar to the control with the injection and the BV-loaded CS-NPs groups being the closest to the control and the irradiated BV-treated group the most deviated, and this was further shown in the histology samples with the presence of excess giant cells in the spleen sections of irradiated BV injected group and a less amount of them in the BV-loaded CS-NPs. The gene discussed is IL6; the disease is bacterial vaginosis.