The data showed that knockdown or overexpression of RBM4 did not significantly impact the mRNA level of LKB1 isoform 1, which encodes the canonical LKB1, or LKB1 isoform 2, the short isoform, in ESCC cells, suggesting that RBM4 could not regulate alternative splicing of LKB1 mRNA (Supplementary Fig. 3d). This evidence concerns the gene STK11 and esophageal squamous cell carcinoma.