RBM4 and cancer: The malfunction of RBPs results in various diseases, including human cancer.38,39 RNA-binding motif 4 (RBM4) has been identified as a potential tumor suppressor to inhibit cancer progression in multiple cancers.39–42 In addition to its classic function as a splicing factor, RBM4 also participates in regulating translation and RNA stability.43–45 However, the potential role of RBM4 in ESCC remains largely unknown.