In addition, overexpression of RBM4 enhanced the glutamine consumption and the concomitant glutamate production in different ESCC cell lines (Fig. 6b), while depletion of RBM4 suppressed the cellular glutamine consumption and glutamate production (Fig. 6c), suggesting that RBM4 might promote glutamine utilization of ESCC cells. The gene discussed is RBM4; the disease is esophageal squamous cell carcinoma.