TRIM26 is a member of the Tripartite motif (TRIM) protein family, which is implicated in innate immunity, DNA damage response, tumor progression.82,83 TRIM26 usually catalyzed the polyubiquitin of its functional targets, such as ZEB1 and SOX2.84,85 Our findings established a novel link between TRIM26 and LKB1 upon the engagement of RBM4, implying that presumably TRIM26 may be involved in the related metabolic processes or metabolic adaptations. This evidence concerns the gene ZEB1 and neoplasm.