The malfunction of RBPs results in various diseases, including human cancer.38,39 RNA-binding motif 4 (RBM4) has been identified as a potential tumor suppressor to inhibit cancer progression in multiple cancers.39–42 In addition to its classic function as a splicing factor, RBM4 also participates in regulating translation and RNA stability.43–45 However, the potential role of RBM4 in ESCC remains largely unknown. This evidence concerns the gene RBM4 and esophageal squamous cell carcinoma.