ITGAV and neoplasm: No significant change in tumor size was observed in the subcutaneous tumorigenesis of the two kinds of cells treated with SEPT11 overexpression, knockout or inhibitor FCF (Supplementary Fig. 3E, F), but AY overexpression could promote tumor enlargement in KO-SEPT11 group (Supplementary Fig. 3F), this implies that AY can induce proliferation through other signals, such as the ITGAV we previously found [5].