Here, obese GRLysMCre mice showed severe insulin resistance in comparison to GRflox mice shown by insulin tolerance test (Fig. 1G) and a decrease in muscle tissue AKT phosphorylation upon insulin injection (Supplementary Fig. S1L), while insulin response in lean mice was indistinguishable between genotypes (Supplementary Fig. S1M). This evidence concerns the gene INS and Insulin resistance.