SOCS3 and obesity due to melanocortin 4 receptor deficiency: These observations indicate that GR loss enhances the obesity-induced response in ATMs, which is a general increase in pro-inflammatory and decrease in anti-inflammatory gene signatures, the latter highlighted by the fact that genes linked to anti-inflammatory macrophage action such as Cd163, Socs3, Mrc1, and Klf4, among others, clearly displayed reduced expression in GR-deficient ATMs (Fig. 2E).