Insulin resistance in obese GRLysMCre mice is likely due to loss of alternatively activated macrophages in adipose tissue since decreased insulin sensitivity can be recapitulated in co-cultures of adipocytes and GR-deficient bone marrow-derived macrophages (BMDM) but not in obese mice devoid of GR in Kupffer cells (GRClec4fCre). The gene discussed is INS; the disease is Insulin resistance.